TY - JOUR AB - In the present study, the protective effect of myricetin administered orally at 200, 100 or 50 mg/kg for 10 days was evaluated in a murine model of acute experimental colitis induced by dextran sulphate sodium (DSS). Macroscopic analysis was carried out to determine the effect of myricetin on pro-inflammatory cytokines, inflammatory markers and oxidative damage in biopsies of colonic tissues. The results showed that treatment with myricetin ameliorated body weight loss in a dose-dependent manner and significantly reduced histology scores. Myricetin decreased the production of nitric oxide (NO), myeloperoxidase (MPO) and malondialdehyde (MDA), while increasing the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Furthermore, the levels of the cytokines interleukin-1β (IL-1β) and interleukin-6 (IL-6) were significantly decreased. Taken together, the results suggest that the anticolitis effects of myricetin may be attributed to anti-inflammatory and antioxidant actions. Additional investigation is required to determine the detailed mechanisms of action. AD - Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, P.R. China College of Pharmacy, Yanbian University, Yanji 133002, P.R. China AU - Zhao,Jing AU - Hong,Tie AU - Dong,Man AU - Meng,Yixiao AU - Mu,Jiaye DA - 2013/02/01 DO - 10.3892/mmr.2012.1225 EP - 570 IS - 2 JO - Mol Med Rep KW - myricetin dextran sulphate sodium ulcerative colitis antioxidation anti-inflammatory PY - 2013 SN - 1791-2997 1791-3004 SP - 565 ST - Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis T2 - Molecular Medicine Reports TI - Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis UR - https://doi.org/10.3892/mmr.2012.1225 VL - 7 ER -