TY - JOUR AB - βig-h3 is an extracellular matrix protein and its expression is highly induced by transforming growth factor (TGF-β). It has also been suggested to play an important role in the growth and invasion of colon and pancreatic cancers. In the present study, we demonstrated that βig-h3 is expressed in mesothelial cells, especially in patients with advanced gastric cancer. The positive rate of βig-h3 was significantly higher in cases with a more invasive and advanced serous-type, with visible peritoneal metastasis, and in peritoneal lavage cytological examination (PLC) (+) and peritoneal lavage fluid CEA mRNA(+) subgroups (p<0.05). Our study also showed that the expression of βig-h3 gradually increased with increasing TGF-β1 concentrations in vitro in a time-dependant manner. In addition, βig-h3 also induced human gastric carcinoma cell line (SGC-7901) cell adhesion in a dose-dependent manner and significantly increased cell migration and proliferation. The results suggest that βig-h3 expression in peritoneal mesothelial cells in gastric cancer patients is a marker of the biological behavior of gastric cancer and plays an important role in the process of peritoneal carcinomatosis. AD - Department of General Surgery, Fourth Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Oncology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China AU - Li,Zhen AU - Miao,Zhifeng AU - Jin,Guanghua AU - Li,Xiaoxia AU - Li,Hongwu AU - Lv,Zhidong AU - Xu,Hui-Mian DA - 2012/09/01 DO - 10.3892/mmr.2012.951 EP - 564 IS - 3 JO - Mol Med Rep KW - βig-h3 gastric cancer peritoneal carcinomatosis PY - 2012 SN - 1791-2997 1791-3004 SP - 558 ST - βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis T2 - Molecular Medicine Reports TI - βig-h3 supports gastric cancer cell adhesion, migration and proliferation in peritoneal carcinomatosis UR - https://doi.org/10.3892/mmr.2012.951 VL - 6 ER -