TY - JOUR AB - Inducible nitric oxide synthase (iNOS) is the key enzyme in NO synthesis and exhibits a high expression in numerous types of malignant tumors. Previous studies have demonstrated that iNOS promotes the production of tumor blood vessels by catalyzing the synthesis of additional NO. Certain experimental evidence has suggested that iNOS may regulate the levels of vascular endothelial growth factor (VEGF), as the level of VEGF may be induced by iNOS during endothelial cell migration and angiogenesis. In this study, it was observed that SiHa and HeLa cells exhibit depressed proliferation levels following the knockdown of iNOS with a lentivirus. In addition, NO levels demonstrated a correlation with VEGF levels in the cell culture supernatant. AD - Obstetrics and Gynecology Hospital, Shanghai Medical College, Fudan University, Shanghai 200011, P.R. China AU - Dong,Jing AU - Cheng,Mingjun AU - Sun,Hong DA - 2014/02/01 DO - 10.3892/mmr.2013.1838 EP - 589 IS - 2 JO - Mol Med Rep KW - inducible nitric oxide synthase cervical cancer cell proliferation vascular endothelial growth factor PY - 2014 SN - 1791-2997 1791-3004 SP - 583 ST - Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor T2 - Molecular Medicine Reports TI - Function of inducible nitric oxide synthase in the regulation of cervical cancer cell proliferation and the expression of vascular endothelial growth factor UR - https://doi.org/10.3892/mmr.2013.1838 VL - 9 ER -