TY - JOUR AB - Parkinson's disease (PD) is one of the most common age‑related neurodegenerative diseases, which results from a number of environmental and inherited factors. PD is characterized by the slow progressive degeneration of dopaminergic (DA) neurons in the substantia nigra. The nigrostriatal DA neurons are particularly vulnerable to inflammatory attack. Neuroinflammation is an important contributor to the pathogenesis of age‑related neurodegenerative disorders, such as PD, and as such anti‑inflammatory agents are becoming a novel therapeutic focus. This review will discuss the current knowledge regarding inflammation and review the roles of intracellular inflammatory signaling pathways, which are specific inflammatory mediators in PD. Finally, possible therapeutic strategies are proposed, which may downregulate inflammatory processes and inhibit the progression of PD. AD - Department of Neurology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China AU - Yan,Junqiang AU - Fu,Qizhi AU - Cheng,Liniu AU - Zhai,Mingming AU - Wu,Wenjuan AU - Huang,Lina AU - Du,Ganqin DA - 2014/11/01 DO - 10.3892/mmr.2014.2563 EP - 2233 IS - 5 JO - Mol Med Rep KW - inflammation Parkinson's disease NR4A DJ‑1 toll‑like receptors cytokines PY - 2014 SN - 1791-2997 1791-3004 SP - 2223 ST - Inflammatory response in Parkinson's disease (Review) T2 - Molecular Medicine Reports TI - Inflammatory response in Parkinson's disease (Review) UR - https://doi.org/10.3892/mmr.2014.2563 VL - 10 ER -