TY - JOUR AB - Vanishing lung syndrome, also known as idiopathic giant bullous emphysema, is a rare disease characterized by giant emphysematous bullae. The disease is diagnosed by radiological findings of giant bullae in one, or both, of the upper lobes of the lung, occupying at least one‑third of the hemithorax. There have been several reports of vanishing lung syndrome, however it remains to be determined whether genetic inheritance is associated with the disease. In the present study, five patients within one family, with vanishing lung syndrome, were reported during a follow‑up period of ~20 years. All of the patients were diagnosed by radiological findings, which showed diffuse bullae in the lungs, which were of varying size and asymmetrical distribution, and the occurrence of pneumothorax or emphysema. The Medical Ethics Committee of the People's Hospital of Zhangye Municipality (Zhangye, China) approved this study, and all subjects gave their informed consent During the follow‑up period of 20 years, bullae in these patients were shown to progressively increase, and no other pulmonary diseases, including lung cancer, tuberculosis, pneumoconiosis and chronic bronchitis were observed. Autosomal dominant inheritance was observed in five cases, and autosomal recessive inheritance was observed in one case. The present study suggests that vanishing lung syndrome may be associated with autosomal dominant and recessive genetic inheritance. AD - Department of Radiology, The People's Hospital of Zhangye Municipality, Zhangye, Gansu 734000, P.R. China Department of Medicine, The People's Hospital of Zhangye Municipality, Zhangye, Gansu 734000, P.R. China Department of Obstetrics and Gynecology, The People's Hospital of Zhangye Municipality, Zhangye, Gansu 734000, P.R. China AU - Gao,Xichun AU - Wang,Haiying AU - Gou,Kaihong AU - Huang,Baosheng AU - Xia,Dongzhou  AU - Wu,Xiuli AU - Wei,Ming AU - Zheng,Shengxi AU - Ma,Shan AU - He,Juanxiang DA - 2015/01/01 DO - 10.3892/mmr.2014.2673 EP - 570 IS - 1 JO - Mol Med Rep KW - vanishing lung syndrome giant bullous emphysema inheritance high-resolution computed tomography PY - 2015 SN - 1791-2997 1791-3004 SP - 567 ST - Vanishing lung syndrome in one family: Five cases with a 20-year follow-up T2 - Molecular Medicine Reports TI - Vanishing lung syndrome in one family: Five cases with a 20-year follow-up UR - https://doi.org/10.3892/mmr.2014.2673 VL - 11 ER -