TY - JOUR AB - Omentin is a novel adipokine, which is expressed in and released from omental adipose tissue. In the present study, the effect of omentin on neural stem cells (NSCs) was investigated. NSCs are a subtype of stem cell in the nervous system, which are able to self‑renew and generate neurons and glia for repairing neural lesions. Mouse NSCs were isolated and cultured in vitro. Treatment with recombinant omentin for 3 and 5 days significantly increased the size of NSC neurospheres (P<0.01) and enhanced NSC cell viability in normal conditions. In addition, omentin protected against the decrease in cell viability induced by the pro‑inflammatory cytokine tumor necrosis factor‑α. In the NSCs, incubation of omentin for 2, 4, 6, 8 and 16 h enhanced the phosphorylation of Akt at the Thr308 site and of AS160 at the Ser318 site, peaking 6 h after treatment. Additionally, treatment with LY294002 (10 µM), a specific inhibitor of phosphatidylinositol 3‑kinase/Akt signaling, eliminated the omentin‑induced increase in neurosphere size and cell viability. Overall, the present study provided the first evidence, to the best of our knowledge, that omentin promotes the growth and survival of NSCs in vitro through activation of the Akt signaling pathway. These results may contribute to the understanding of the role of omentin in the nervous system. AD - Department of Ultrasound, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of Nephrology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China Department of Hand Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China AU - Zhao,Li‑Rong AU - Du,Yu‑Jun AU - Chen,Lei AU - Liu,Zhi‑Gang AU - Jia,Xiao‑Yan  AU - Pan,Yue‑Hai AU - Liu,Jian‑Feng AU - Liu,Bin DA - 2015/03/01 DO - 10.3892/mmr.2014.2937 EP - 1864 IS - 3 JO - Mol Med Rep KW - omentin neural stem cells Akt PY - 2015 SN - 1791-2997 1791-3004 SP - 1859 ST - Omentin-1 promotes the growth of neural stem cells via activation of Akt signaling T2 - Molecular Medicine Reports TI - Omentin-1 promotes the growth of neural stem cells via activation of Akt signaling UR - https://doi.org/10.3892/mmr.2014.2937 VL - 11 ER -