TY - JOUR AB - Piperlonguminine (PL), a key compound from the Piper longum fruit, is known to exhibit anti‑tumor and anti‑inflammatory activities. However, little is known about its effects on collagen‑induced arthritis (CIA). Fibroblast‑like synoviocytes (FLS) have a pivotal role in the development of rheumatoid arthritis (RA). Myeloid‑derived suppressor cells (MDSCs) are able to suppress T cell responses and have important roles in the regulation of autoimmune arthritis. The current study investigated whether PL alters the progression of RA. It was determined that PL reduces the arthritis score and histopathologic lesions in a mouse model of CIA. PL also reduces the expression levels of serum anti‑collagen II antibodies (anti‑CⅡ), tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β, IL‑23 and IL‑17 in CIA mice. In draining lymph nodes (DLNs), MDSCs were significantly expanded, however, the number of Th17 cells was markedly decreased by PL treatment. Additionally, PL reduced secretion of IL‑1β, IL‑23 and IL‑17 by TNF‑α‑stimulated human RA FLS. PL significantly inhibited the migration and invasion of TNF‑α‑stimulated human RA FLS. These results indicate that PL may be a candidate therapeutic agent for the treatment of RA, via the expansion of MDSCs and the inhibition of the Th17 response and activation of FLS. AD - Department of Orthopedics, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, P.R. China Department of Orthopedics and Traumatology, Qidong Hospital of Traditional Chinese Medicine, Nantong, Jiangsu 421600, P.R. China AU - Sun,Jian AU - Xu,Ping AU - Du,Xueping AU - Zhang,Qinggang AU - Zhu,Yuchang DA - 2015/04/01 DO - 10.3892/mmr.2014.3001 EP - 2694 IS - 4 JO - Mol Med Rep KW - piperlongumine rheumatoid arthritis collagen‑induced arthritis myeloid‑derived suppressor cells fibroblast‑like synoviocytes PY - 2015 SN - 1791-2997 1791-3004 SP - 2689 ST - Piperlongumine attenuates collagen-induced arthritis via expansion of myeloid-derived suppressor cells and inhibition of the activation of fibroblast-like synoviocytes T2 - Molecular Medicine Reports TI - Piperlongumine attenuates collagen-induced arthritis via expansion of myeloid-derived suppressor cells and inhibition of the activation of fibroblast-like synoviocytes UR - https://doi.org/10.3892/mmr.2014.3001 VL - 11 ER -