TY - JOUR AB - MicroRNA (miR)-9 has been demonstrated to regulate the radiosensitivity of tumor cells. In the present study, the mechanism by which miR‑9 modulates the sensitivity of nasopharyngeal carcinoma (NPC) cells to ultraviolet (UV) radiation was investigated. The results demonstrated that exposure of NPC cells to UV light resulted in a significant increase in the expression of miR‑9, and that CNE2 cells overexpressing miR‑9 exhibited reduced levels of DNA damage and increased levels of total glutathione upon UV exposure. Accordingly, the inhibition of the expression of miR‑9 promoted UV‑induced DNA damage and apoptosis. Although miR‑9 inhibited the expression of E‑cadherin in the CNE2 cells and increased their resistance to UV radiation, the use of small interfering RNA to inhibit the expression of E‑cadherin was not sufficient to decrease the radiosensitivity of the NPC cells. These data demonstrated that miR‑9 did not modulate the sensitivity of the CNE2 cells to UV radiation through E‑cadherin, but suggested that miR‑9 regulated radiosensitivity through its effects on glutathione. These findings suggest that miR‑9 may be a potential target for modulating the radiosensitivity of NPC cells. AD - Department of Otorhinolaryngology, The First Affiliated Hospital and Otorhinolaryngology Institute, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China Department of Otolaryngology, First People's Hospital, Foshan, Guangdong 528000, P.R. China AU - Zheng,Chao‑Pan AU - Han,Ling AU - Hou,Wei‑Jian AU - Tang,Jun AU - Wen,Yi‑Hui AU - Fu,Ran AU - Wang,Yue‑Jian AU - Wen,Wei‑Ping DA - 2015/08/01 DO - 10.3892/mmr.2015.3622 EP - 2373 IS - 2 JO - Mol Med Rep KW - microRNA-9 radiosensitivity CNE2 E-cadherin ultraviolet rays PY - 2015 SN - 1791-2997 1791-3004 SP - 2367 ST - MicroRNA-9 suppresses the sensitivity of CNE2 cells to ultraviolet radiation T2 - Molecular Medicine Reports TI - MicroRNA-9 suppresses the sensitivity of CNE2 cells to ultraviolet radiation UR - https://doi.org/10.3892/mmr.2015.3622 VL - 12 ER -