TY - JOUR AB - Psoriasis, a chronic inflammatory skin disease, is caused by infiltrating lymphocytes and associated cytokines, including tumor necrosis factor (TNF)α, interleukin (IL)‑6, and IL‑17. Effective treatments, including pathogenesis‑based biological agents against psoriasis, are currently under development. Although the role of reactive oxygen species (ROS) in the pathogenesis of psoriasis has been investigated, it remains to be fully elucidated; ROS‑targeted therapeutic strategies are also lacking at present. Therefore, the objective of the present study was to assess whether H2, a ROS scavenger, has a therapeutic effect on psoriasis‑associated inflammation by reducing hydroxyl radicals or peroxynitrite in the immunogenic psoriasis cascade. Three methods were used to administer H2: Drop infusion of saline containing 1 ppm H2 (H2‑saline), inhalation of 3% H2 gas, and drinking of water containing a high concentration (5‑7‑ppm) of H2 (high‑H2 water). Treatment efficacy was estimated using the disease activity score 28 (DAS28) system, based on C‑reactive protein levels, and the psoriasis area and severity index (PASI) score, determined at baseline and following each H2 treatment. Furthermore, levels of TNFα, IL‑6, and IL‑17 were analyzed. The DAS28 and PASI score of the three patients decreased during H2 treatment, regardless of the administration method. The psoriatic skin lesions almost disappeared at the end of the treatment. IL‑6 levels decreased during H2 treatment in Case 1 and 2. IL‑17, whose concentration was high in Case 1, was reduced following H2 treatment, and TNFα also decreased in Case 1. In conclusion, H2 administration reduced inflammation associated with psoriasis in the three cases examined and it may therefore be considered as a treatment strategy for psoriasis‑associated skin lesions and arthritis. AD - Department of Rheumatology and Orthopaedic Surgery, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan Department of Dermatology, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan MiZ Company, Fujisawa, Kanagawa 251‑0871, Japan Department of Radiology, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan Department of Internal Medicine, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan Department of Orthopaedic Surgery, Kyushu University, Higashi‑Ku, Fukuoka 812‑8582, Japan Department of Cardiology, Haradoi Hospital, Higashi‑ku, Fukuoka 813‑8588, Japan Midorino Clinic, Higashi‑ku, Fukuoka 813‑0025, Japan AU - Ishibashi,Toru AU - Ichikawa,Miki AU - Sato,Bunpei AU - Shibata,Shinji AU - Hara,Yuichi AU - Naritomi,Yuji AU - Okazaki,Ken AU - Nakashima,Yasuharu AU - Iwamoto,Yukihide AU - Koyanagi,Samon AU - Hara,Hiroshi AU - Nagao,Tetsuhiko DA - 2015/08/01 DO - 10.3892/mmr.2015.3707 EP - 2764 IS - 2 JO - Mol Med Rep KW - psoriasis arthritis molecular hydrogen 7 ppm H2-saline H2 gas PY - 2015 SN - 1791-2997 1791-3004 SP - 2757 ST - Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases T2 - Molecular Medicine Reports TI - Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases UR - https://doi.org/10.3892/mmr.2015.3707 VL - 12 ER -