TY - JOUR AB - Studies using animal models have demonstrated that probiotics may have a beneficial role in the prevention of colorectal cancer (CRC); however, the underlying mechanism of the beneficial effects of interventional probiotic treatment on gut microbiota has remained elusive. In the present study, pyrosequencing of the V3 region of the 16S rRNA genes was conducted in order to determine the extent to which probiotics alter the microbiota. The observations of the present study indicated that the microbial structure of cancerous tissue differed significantly from that of healthy individuals and that the CRC microbiota exhibited lower diversity. It was indicated that interventional treatment with probiotics increased the density and diversity of mucosal microbes, and altered the mucosa‑associated microbiota. Pyrosequencing demonstrated that probiotics significantly reduced (5‑fold) the abundance of a bacterial taxon assigned to the genus Fusobacterium, which had been previously suggested to be a contributing factor to increase tumorigenesis. Accordingly, interventional probiotic therapy is suggested to be able to improve the composition of the mucosal microbial flora and significantly reduce the abundance of mucosa-associated pathogens in patients with CRC. AD - Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China AU - Gao,Zhiguang AU - Guo,Bomin AU - Gao,Renyuan AU - Zhu,Qingchao AU - Wu,Wen AU - Qin,Huanlong DA - 2015/10/01 DO - 10.3892/mmr.2015.4124 EP - 6127 IS - 4 JO - Mol Med Rep KW - probiotics mucosa-associated microbiota colorectal cancer Fusobacterium dysbiosis PY - 2015 SN - 1791-2997 1791-3004 SP - 6119 ST - Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer T2 - Molecular Medicine Reports TI - Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer UR - https://doi.org/10.3892/mmr.2015.4124 VL - 12 ER -