TY - JOUR AB - Allergic asthma is a chronic inflammatory disease that is regulated by coordination of T‑helper type 2 cell cytokines and inflammatory signaling molecules. Ginsenoside Rh2 (G‑Rh2) is an active component of ginseng with anti‑inflammatory and anti‑tumor effects. The aim of the present study was to determine the inhibitory effects of G‑Rh2 on allergic airway inflammation in a murine model of asthma, in which mice develop the following pathophysiological features of asthma: Increased abundance of inflammatory cells; increased levels of interleukin‑4 (IL‑4), IL‑5 and IL‑13; decreased abundance of interferon gamma in the bronchoalveolar lavage fluid and lung tissue; increased total and ovalbumin (OVA)‑specific immunoglobulin E (IgE) levels in the serum; increased airway hyperresponsiveness (AHR); and activation of nuclear factor kappa B (NF‑κB) in lung tissue. In the asthmatic mice, administration of G‑Rh2 markedly reduced peribronchiolar inflammation, recruitment of airway inflammatory cells, cytokine production, total and OVA‑specific IgE levels and AHR. G‑Rh2 administration inhibited NF‑κB activation and p38 mitogen-activated protein kinase (MAPK) phosphorylation induced by OVA inhalation. These results suggested that G‑Rh2 attenuates allergic airway inflammation by regulating NF‑κB activation and p38 MAPK phosphorylation. The present study identified the molecular mechanisms of action of G-Rh2, which supported the potential use of G‑Rh2 to prevent and/or treat asthma and other airway inflammatory disorders. AD - Department of Anatomy, Histology and Embryology, Yanbian University School of Basic Medical Sciences, Yanbian, Jilin 133002, P.R. China Department of Respiratory Medicine, Yanbian University, Yanbian, Jilin 133000, P.R. China College of Pharmacy, Yanbian University, Yanbian, Jilin 133002, P.R. China Department of Pathology, Yanbian University School of Basic Medical Sciences, Yanbian, Jilin 133000, P.R. China Department of Anatomy, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561‑756, Republic of Korea AU - Li,Liang,Chang AU - Piao,Hong ,Mei AU - Zheng,Ming,Yu AU - Lin,Zhen ,Hua AU - Choi,Yun ,Ho AU - Yan,Guang ,Hai DA - 2015/11/01 DO - 10.3892/mmr.2015.4272 EP - 6954 IS - 5 JO - Mol Med Rep KW - ginsenoside Rh2 asthma nuclear factor‑kappa B airway inflammation T helper cell type 2 cytokines PY - 2015 SN - 1791-2997 1791-3004 SP - 6946 ST - Ginsenoside Rh2 attenuates allergic airway inflammation by modulating nuclear factor‑κB activation in a murine model of asthma T2 - Molecular Medicine Reports TI - Ginsenoside Rh2 attenuates allergic airway inflammation by modulating nuclear factor‑κB activation in a murine model of asthma UR - https://doi.org/10.3892/mmr.2015.4272 VL - 12 ER -