TY - JOUR AB - In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood‑retinal barrier (BRB) and retinal neovascularization; however, how AGEs affect the retina has largely remained elusive. OSSC1E‑K19 is a novel phytochemical component of Osteomeles schwerinae. The objective of the present study was to evaluate the protective effects of OSSC1E‑K19 on retinal vascular injury in AGE‑modified rat serum albumin (AGE-RSA)-induced retinopathy. AGE-RSA-injected rat eyes were used investigate the protective effects of OSSC1E‑K19 on BRB breakdown. Intravitreal injection of OSSC1E-K19 prevented AGE-RSA-induced BRB breakdown and decreased retinal VEGF expression in retinal vessels. In addition, OSSC1E-K19 inhibited the loss of occludin, a significant tight junction protein. These results supported the potential therapeutic utility of OSSC1E-K19 for retinal vascular permeability diseases. AD - Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 305‑811, Republic of Korea Korea Natural Products Development Laboratory, International Ginseng and Herb Research Institute, Geumsan, South Chungcheong 312‑804, Republic of Korea AU - Kim,Chan‑Sik AU - Kim,Junghyun AU - Jo,Kyuhyung AU - Lee,Yun ,Mi AU - Sohn,Eunjin AU - Yoo,Nam ,Hee AU - Kim,Jin ,Sook DA - 2015/11/01 DO - 10.3892/mmr.2015.4413 EP - 7284 IS - 5 JO - Mol Med Rep KW - Osteomeles schwerinae diabetic retinopathy advanced glycation end products vascular endothelial growth factor blood-retinal barrier PY - 2015 SN - 1791-2997 1791-3004 SP - 7279 ST - OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats T2 - Molecular Medicine Reports TI - OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats UR - https://doi.org/10.3892/mmr.2015.4413 VL - 12 ER -