TY - JOUR AB - Renal cell carcinoma (RCC) is the most common type of renal tumor, which has a poor prognosis. Improvements in understanding the underlying molecular biology of RCC has led to systemic treatments, which have markedly improved patient outcomes. Therefore, it is necessary and worthwhile to identify novel biomarkers for RCC. MicroRNAs (miRNAs) have been found to be important in a wide range of biological and pathological processes, including cell differentiation, migration, growth, proliferation, apoptosis and metabolism. Aberrant expression of miRNA‑130b has previously been reported in tumors, however, its role in RCC remains to be elucidated. In the present study, the upregulation of miR‑130b was observed in RCC tissues and cell lines using reverse transcription‑quantitative polymerase chain reaction analysis, which was consistent with previous microRNA profiling in RCC. Furthermore, the effects of miR‑130b on cell migration, proliferation and apoptosis were examined using a wound scratch assay, an MTT assay and flow cytometric analysis, respectively. The results demonstrated that the downregulation of miR‑130b by a synthesized inhibitor inhibited cell migration, suppressed cell proliferation and induced RCC cell apoptosis. The present study was the first, to the best of our knowledge, to suggest that miR‑130b may be a promising biomarker for diagnosis and a therapeutic target for the treatment of RCC. Further investigations are required to examine the roles and target genes of miR‑130b in RCC. AD - Department of Urology, Peking University Shenzhen Hospital, Shenzhen PKU‑HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China Department of Urology, Anhui Medical University, Hefei, Anhui 230032, P.R. China Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU‑HKUST Medical Center, Shenzhen, Guangdong 518036, P.R. China AU - Li,Yifan AU - Chen,Duqun AU - Li,Yuchi AU - Jin,Lu AU - Liu,Jiaju AU - Su,Zhengming AU - Qi,Zhengyu AU - Shi,Min AU - Jiang,Zhimao AU - Gui,Yaoting AU - Yang,Shangqi AU - Mao,Xiangming AU - Lai,Yongqing DA - 2016/02/01 DO - 10.3892/mmr.2015.4744 EP - 1908 IS - 2 JO - Mol Med Rep KW - microRNA miR‑130b renal cell carcinoma oncogene PY - 2016 SN - 1791-2997 1791-3004 SP - 1902 ST - Identification of miR‑130b as an oncogene in renal cell carcinoma T2 - Molecular Medicine Reports TI - Identification of miR‑130b as an oncogene in renal cell carcinoma UR - https://doi.org/10.3892/mmr.2015.4744 VL - 13 ER -