TY - JOUR AB - Skeletal muscle atrophy, a conventional clinical feature in patients with cancer, chronic obstructive pulmonary disease, sepsis and severe burns, is defined as a reduction in muscle mass. During atrophy, the protein degradation is abnormally activated and the aberrance between protein synthesis and protein degradation results in muscle atrophy. Previous studies have demonstrated that miRNAs, small non‑coding RNA molecules, serve an important role in the regulation of muscle atrophy. Further studies have indicated the implications of the ubiquitin‑proteasome and PI3K/Akt/FoxO signaling pathways and myogenic regulatory factors in miRNA‑mediated muscle atrophy. Therefore, in this review, the effects and molecular mechanisms of miRNAs on muscle atrophy are summarized, leading to the suggestion that miRNAs may serve as potential therapeutic targets in muscle atrophy. AD - Burn and Plastic Surgery Department, The First Affiliated Hospital to People's Liberation Army General Hospital, Beijing 100048, P.R. China AU - Yu,Yonghui AU - Chu,Wanli AU - Chai,Jiake AU - Li,Xiao AU - Liu,Lingying AU - Ma,Li DA - 2016/02/01 DO - 10.3892/mmr.2015.4748 EP - 1474 IS - 2 JO - Mol Med Rep KW - miRNA protein degradation differentiation myogenesis muscle atrophy PY - 2016 SN - 1791-2997 1791-3004 SP - 1470 ST - Critical role of miRNAs in mediating skeletal muscle atrophy (Review) T2 - Molecular Medicine Reports TI - Critical role of miRNAs in mediating skeletal muscle atrophy (Review) UR - https://doi.org/10.3892/mmr.2015.4748 VL - 13 ER -