TY - JOUR AB - Arterial remodeling is a pathogenic occurrence during hypertension and, in turn, is closely associated with the development and complications of hypertension. Grape seed proanthocyanidin extract (GSPE) has been reported to exhibit a protective effect on cardiovascular disease, however its effect on arterial remodeling remains to be fully elucidated. In the present study, the effects of GSPE on arterial remodeling were analyzed by treating spontaneously hypertensive rats (SHRs) with GSPE (250 mg/kg·day). Arterial remodeling was quantified through morphological methods; thoracic aortas were stained with hematoxylin-eosin or sirius red‑victoria blue. The arterial ultrastructure was imaged using transmission electron microscopy. The content of nitric oxide (NO) and endothelin‑1 (ET‑1) were examined to determine endothelial function. Oxidative stress was assessed by malondialdehyde (MDA) levels and the activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). Administration of GSPE markedly alleviated hypertension‑induced arterial remodeling, which was not associated with blood pressure control. ET‑1 production was reduced, while NO production was increased in the GSPE group, which exhibited improved endothelial function. In addition, treatment with GSPE significantly ameliorated oxidative stress by improving SOD and CAT activities and reducing MDA formation. In conclusion, GSPE may attenuate hypertension‑induced arterial remodeling by repressing oxidative stress and is recommended as a potential anti‑arterial remodeling agent for patients with hypertensive vascular diseases. AD - Department of Geriatric Cardiology, Qianfoshan Hospital of Shandong University, Jinan, Shandong 250013, P.R. China Department of Geriatric Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China AU - Liang,Ying AU - Wang,Jian AU - Gao,Haiqing AU - Wang,Quanzhen AU - Zhang,Jun AU - Qiu,Jie DA - 2016/10/01 DO - 10.3892/mmr.2016.5699 EP - 3718 IS - 4 JO - Mol Med Rep KW - grape seed proanthocyanidin extract arterial remodeling oxidative stress hypertension PY - 2016 SN - 1791-2997 1791-3004 SP - 3711 ST - Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress T2 - Molecular Medicine Reports TI - Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress UR - https://doi.org/10.3892/mmr.2016.5699 VL - 14 ER -