TY - JOUR AB - MicroRNAs (miRs), a class of non-coding RNAs that are 18‑25 nucleotides in length, serve as key regulators in the development and progression of human cancers. Previously, miR‑503 has been implicated in breast cancer. However, the underlying mechanism of miR‑503 in regulating the proliferation and invasion of breast cancer cells remains largely unknown. In the present study, reverse transcription‑quantitative polymerase chain reaction analysis indicated that the expression of miR‑503 was significantly reduced in breast cancer tissues compared with their matched adjacent normal tissues. Furthermore, miR‑503 expression levels were markedly reduced in T2‑T4 stage breast cancer, compared with T1 stage. Insulin‑like growth factor 1 receptor (IGF‑1R) was further identified as a novel target of miR‑503. Overexpression of miR‑503 significantly suppressed the protein expression levels of IGF‑1R. Furthermore, it inhibited the proliferation and invasion of human breast cancer MCF‑7 cells, as assessed by MTT and Transwell assays, respectively. However, restoration of IGF‑1R expression markedly ameliorated the suppressive effects of miR‑503 overexpression on MCF‑7 cell proliferation and invasion, indicating that miR‑503 inhibits breast cancer cell proliferation and invasion at least partially via directly targeting IGF‑1R. Furthermore, the mRNA and protein expression levels of IGF‑1R were demonstrated to be significantly increased in breast cancer tissues compared with their matched adjacent normal tissues. In addition, IGF‑1R mRNA expression levels were reversely correlated with miR‑503 expression levels in breast tumors, suggesting that the upregulation of IGF‑1R may be due to downregulation of miR‑503 in breast cancer. In conclusion, the present study expanded the understanding of the regulatory mechanism of miR‑503 in breast cancer, and implicates the miR‑503/IGF‑1R axis as a potential therapeutic target for breast cancer. AD - Department of General Surgery, Xinxiang Center Hospital, Xinxiang, Henan 453000, P.R. China Department of Oncology, People's Hospital of Xixia County, Nanyang, Henan 474550, P.R. China AU - Yan,Jingwang AU - Xu,Yonghuan AU - Wang,Haipeng AU - Du,Taiping AU - Chen,Hao DA - 2017/08/01 DO - 10.3892/mmr.2017.6816 EP - 1714 IS - 2 JO - Mol Med Rep KW - breast cancer microRNA‑503 insulin‑like growth factor 1 receptor proliferation invasion PY - 2017 SN - 1791-2997 1791-3004 SP - 1707 ST - MicroRNA-503 inhibits the proliferation and invasion of breast cancer cells via targeting insulin-like growth factor 1 receptor Retraction in /10.3892/mmr.2022.12651 T2 - Molecular Medicine Reports TI - MicroRNA-503 inhibits the proliferation and invasion of breast cancer cells via targeting insulin-like growth factor 1 receptor Retraction in /10.3892/mmr.2022.12651 UR - https://doi.org/10.3892/mmr.2017.6816 VL - 16 ER -