TY - JOUR AB - Vascular inflammation may induce a number of diseases, including organ damage or failure, heart attack and stroke. The present study aimed to investigate the use of wogonin, a compound extracted from herbs, to mediate inflammatory reactions in vascular inflammation. Wogonin was loaded in a well‑characterized polymeric biomaterial carrier. In mice with streptozotocin‑induced vascular inflammation, wogonin treatment regulated the production of inflammatory cytokines, including interleukin‑6, tumor necrosis factor‑α and granulocyte macrophage colony‑stimulating factor. To understand the impact of wogonin on major immune cells, macrophages were treated with wogonin in vitro. It was determined that wogonin did not affect macrophage viability, and that wogonin regulated the relative ratio of M1 versus M2 macrophages. In addition, in co‑culture, wogonin decreased inflammatory cytokine production and regulated the activation of macrophage surface markers including CD80, CD86 and CD40. Results from the present study may aid in our understanding of the effects of wogonin in regulating inflammation, especially its effects on macrophages. AD - Department of Paediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250033, P.R. China Department of Paediatrics, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China Department of Paediatrics, Rizhao People's Hospital, Rizhao, Shandong 276800, P.R. China AU - Wang,Jingwei AU - Li,Kunxia AU - Li,Yupeng AU - Wang,Yulin DA - 2017/12/01 DO - 10.3892/mmr.2017.7611 EP - 8440 IS - 6 JO - Mol Med Rep KW - vascular inflammation wogonin macrophage cytokines surface markers PY - 2017 SN - 1791-2997 1791-3004 SP - 8434 ST - Mediating macrophage immunity with wogonin in mice with vascular inflammation T2 - Molecular Medicine Reports TI - Mediating macrophage immunity with wogonin in mice with vascular inflammation UR - https://doi.org/10.3892/mmr.2017.7611 VL - 16 ER -