TY - JOUR AB - MicroRNA (miR)‑455‑5p has been identified as a biomarker for various types of cancer and may therefore be involved in the regulation of cancer development and progression. However, the specific role and function of miR‑455‑5p in breast cancer remains unclear. The present study explored the expression levels and function of miR‑455‑5p in breast cancer. The results from reverse transcription‑quantitative polymerase chain reaction analysis revealed that miR‑455‑5p was significantly upregulated in breast cancer. Clinically, increased expression of miR‑455‑5p predicted a poor survival rate and miR‑455‑5p was identified as one of the independent prognostic factors for breast cancer patients. Furthermore, results from wound healing and Transwell assays revealed that miR‑455‑5p accelerated invasiveness and migration capabilities of breast cancer cells. In addition, programmed cell death 4 was identified as a downstream target of miR‑455‑5p and its expression was observed to be negatively regulated by miR‑455‑5p. Overall, miR‑455‑5p may function as an oncogene in breast cancer, and may therefore be used as a prognostic marker for breast cancer patients. AD - Department of General Medicine, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China Department of Mammary Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, P.R. China AU - Aili,Tuerxunjiang AU - Paizula,Xuelaiti AU - Ayoufu,Aisikeer DA - 2018/01/01 DO - 10.3892/mmr.2017.8101 EP - 1832 IS - 1 JO - Mol Med Rep KW - MicroRNA‑455‑5p breast cancer migration invasion PY - 2018 SN - 1791-2997 1791-3004 SP - 1825 ST - miR‑455‑5p promotes cell invasion and migration in breast cancer T2 - Molecular Medicine Reports TI - miR‑455‑5p promotes cell invasion and migration in breast cancer UR - https://doi.org/10.3892/mmr.2017.8101 VL - 17 ER -