TY - JOUR AB - Bee venom (BV) has long been used as anti-inflammatory agent in traditional oriental medicine; however, the effect of BV on chronic rhinosinusitis (CRS) is not commonly studied. The aim of the present study was to determine the anti-inflammatory effect of BV on an allergic CRS mouse model. An allergic CRS mouse model was established following the administration of ovalbumin with Staphylococcus aureus enterotoxin B (SEB) into the nose. A total of 0.5 or 5 ng/ml of BV were intranasally applied 3 times a week for 8 weeks. Histopathological alterations were observed using hematoxylin and eosin, and Periodic acid Schiff staining. The levels of inflammatory cell infiltration, interleukin (IL)‑4, IL‑10 and interferon (INF)‑γ in nasal lavage fluid (NLF) were measured. Nuclear factor (NF)‑κB and activator protein (AP)‑1 expressions were also determined by immunohistochemical staining. The group treated with BV had significantly decreased inflammatory cell infiltration and PAS‑positive cells. The levels of INF‑γ, and neutrophil and eosinophil counts in NLF were significantly decreased, and the SEB‑induced NF‑κB and AP‑1 expressions in mouse nasal mucosa were significantly suppressed by 0.5 and 5 ng/ml BV. Thus, BV exerted significant anti‑inflammatory effects in an allergic CRS mouse model and may have potential value for the treatment of CRS. AD - Department of Otolaryngology‑Head and Neck Surgery, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42472, Republic of Korea AU - Shin,Seung‑Heon AU - Ye,Mi‑Kyung AU - Choi,Sung‑Yong AU - Park,Kwan‑Kyu DA - 2018/05/01 DO - 10.3892/mmr.2018.8720 EP - 6638 IS - 5 JO - Mol Med Rep KW - bee venom chronic rhinosinusitis Staphylococcus enterotoxin B mouse model PY - 2018 SN - 1791-2997 1791-3004 SP - 6632 ST - Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model T2 - Molecular Medicine Reports TI - Anti-inflammatory effect of bee venom in an allergic chronic rhinosinusitis mouse model UR - https://doi.org/10.3892/mmr.2018.8720 VL - 17 ER -