TY - JOUR AB - Osteoarthritis (OA) is a common degenerative joint disease in older adults. A number of previous studies have demonstrated that natural flavonoids can serve as promising therapeutic drugs for OA. Kaempferol, a phytochemical ingredient mainly present in various fruits, has exhibited its prominent anti‑inflammatory and antioxidant effects in numerous diseases. However, whether Kaempferol ameliorates the deterioration of arthritis remains to be elucidated. The aim of the present study was to investigate the therapeutic role of Kaempferol on OA in rat chondrocytes. The results revealed that Kaempferol significantly inhibited the interleukin (IL)‑1β‑induced protein expression of inflammatory mediators such as inducible nitric oxide synthase and cyclo‑oxygenase‑2. In addition, the common matrix degrading enzymes [matrix metalloproteinase (MMP)‑1, MMP‑3, MMP‑13 and a disintegrin and metalloproteinase with thrombospondin motif‑5] induced by IL‑1β were also suppressed by Kaempferol, and consequently abolished the degradation of collagen II. Furthermore, the anti‑inflammatory effect of Kaempferol was mediated by the inhibition of the mitogen activated protein kinase‑associated extracellular signal‑regulated kinase and P38 signaling pathways. These results collectively indicated that Kaempferol can potentially prevent OA development and serve as a novel pharmacological target in the treatment of OA. AD - Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China AU - Huang,Xiaojian AU - Pan,Qiyong AU - Mao,Zekai AU - Wang,Pengcheng AU - Zhang,Rui AU - Ma,Xiaohu AU - Chen,Jingyuan AU - You,Hongbo DA - 2018/09/01 DO - 10.3892/mmr.2018.9280 EP - 2704 IS - 3 JO - Mol Med Rep KW - kaempferol mitogen activated protein kinase matrix metalloproteinases a disintegrin and metalloproteinase withthrombospondin motif‑5 collagen II PY - 2018 SN - 1791-2997 1791-3004 SP - 2697 ST - Kaempferol inhibits interleukin‑1β stimulated matrix metalloproteinases by suppressing the MAPK‑associated ERK and P38 signaling pathways T2 - Molecular Medicine Reports TI - Kaempferol inhibits interleukin‑1β stimulated matrix metalloproteinases by suppressing the MAPK‑associated ERK and P38 signaling pathways UR - https://doi.org/10.3892/mmr.2018.9280 VL - 18 ER -