TY - JOUR AB - Proteoglycan (PG) is a complex glycohydrate, which is widely distributed in the extracellular matrix. It has been reported that daily oral administration of PG (extracted from salmon nasal cartilage) modulates the severity of proinflammatory cytokine responses in mouse experimental colitis, autoimmune encephalomyelitis, collagen‑induced arthritis and obesity‑induced inflammation. The present study investigated the effect of salmon nasal cartilage PG on allergic responses using a mouse model of papain‑induced respiratory inflammation. Low titers of immunoglobulin E were identified in the sera of the PG‑administered mice. Oral administration of PG attenuated eosinophil infiltration in the lung. In the acute model of papain‑induced allergic inflammation, PG‑administered mice exhibited low titers of epithelium‑derived and T helper 2‑associated cytokines. The results of the present study demonstrated that salmon cartilage PG has an immunomodulatory effect on intranasally delivered papain. These results suggest a potential role for PG as a prophylactic agent which may attenuate allergic respiratory inflammation. AD - Laboratory of Zoonoses, Kitasato University School of Veterinary Medicine, Towada, Aomori 034‑8628, Japan Tohoku Women's College, Hirosaki, Aomori 036‑8503, Japan Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan Research and Development Department, Ichimaru Pharcos Co., Ltd., Motosu, Gifu 501‑0475, Japan AU - Ono,Hisaya ,K. AU - Yoshimura,Sayuri AU - Hirose,Shouhei AU - Narita,Kouji AU - Tsuboi,Makoto AU - Asano,Krisana AU - Nakane,Akio DA - 2018/10/01 DO - 10.3892/mmr.2018.9364 EP - 4064 IS - 4 JO - Mol Med Rep KW - proteoglycan salmon cartilage prophylactic agent allergy asthma PY - 2018 SN - 1791-2997 1791-3004 SP - 4058 ST - Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation T2 - Molecular Medicine Reports TI - Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation UR - https://doi.org/10.3892/mmr.2018.9364 VL - 18 ER -