TY - JOUR AB - Dysbiosis of the enteric microbiota causes gastrointestinal diseases, including colitis. The present study investigated the beneficial effect of Lactobacillus plantarum 06CC2 in experimental colitis in mice. An experimental colitis model in C57BL6 mice was induced using dextran sulfate sodium. Mice were orally administered 06CC2 (06CC2 group) or PBS only (control group) by gavage. The disease activity index (DAI), histological grading, and colon tissue and colonic lamina propria mononuclear cells (LPMCs) were examined macroscopically and histopathologically, and the expression levels of inflammation‑associated cytokines (IL‑6, IL‑12, TNF‑α and IL‑10) in these samples were determined. Compared with the control group, the 06CC2 group exhibited a significantly lower DAI (1.5±0.8 vs. 0.2±0.3, respectively; P<0.05) and pathology score (6.3±1.5 vs. 3.8±1.3, respectively; P<0.05). IL‑10 expression in colonic LPMCs was higher in the 06CC2 group than in the control group, although there was no significant difference in IFN‑γ, IL‑6 or IL‑12 expression in colonic LPMCs between the two groups. In addition, 06CC2 stimulated the production of IL‑10 from CD11b‑positive cells and CD11c‑positive cells in the colon. The 06CC2 strain induced IL‑10 production in the colon and attenuated colon inflammation. AD - Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890‑8544, Japan Research and Development Division, Minami Nihon Rakuno Kyodo Co., Ltd., Miyazaki 885‑0073, Japan Department of Animal Science and Biotechnology, School of Veterinary Medicine, Azabu University, Kanagawa 252‑5201, Japan AU - Tanaka,Akihito AU - Kanmura,Shuji AU - Morinaga,Yuko AU - Kawabata,Katsuto AU - Arima,Shiho AU - Sasaki,Fumisato AU - Nasu,Yuichirou AU - Tanoue,Shiroh AU - Hashimoto,Shinichi AU - Takeshita,Masahiko AU - Takeda,Shiro AU - Ido,Akio DA - 2020/03/01 DO - 10.3892/mmr.2020.10925 EP - 1191 IS - 3 JO - Mol Med Rep KW - colitis inflammatory bowel disease Lactobacillus microbiota interleukin‑10 Lactobacillus plantarum 06CC2 PY - 2020 SN - 1791-2997 1791-3004 SP - 1181 ST - Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response T2 - Molecular Medicine Reports TI - Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response UR - https://doi.org/10.3892/mmr.2020.10925 VL - 21 ER -