TY - JOUR AB - Apoptosis of pancreatic β‑cells is involved in the pathogenesis of type I and II diabetes. Peroxiredoxin I (Prx I) serves an important role in regulating cellular apoptosis; however, the role of Prx I in pancreatic β‑cell apoptosis is not completely understood. In the present study, the role of peroxiredoxin 1 (Prx I) during streptozotocin (STZ)‑induced apoptosis of pancreatic β‑cells was investigated. The expression level of Prx I was decreased by STZ treatment in a time‑dependent manner, and apoptosis of Prx I knockdown MIN6 cells was increased by STZ stimulation, compared with untransduced MIN6 cells. Furthermore, an intraperitoneal injection of STZ increased pancreatic islet damage in Prx I knockout mice, compared with wild‑type and Prx II knockout mice. AKT and glycogen synthase kinase (GSK)‑3β phosphorylation significantly decreased following Prx I knockdown in MIN6 cells. However, phosphorylated β‑catenin and p65 levels significantly increased after STZ stimulation, compared with untransduced cells. The results of the present study indicate that deletion of Prx I mediated STZ‑induced pancreatic β‑cell death in vivo and in vitro by regulating the AKT/GSK‑3β/β‑catenin signaling pathway, as well as NF‑κB signaling. These findings provide a theoretical basis for treatment of pancreatic damage. AD - Laboratory of Disease Model Research Center, College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China Department of Library and Information Center, Library of Heilongjiang Bayi Agricultural University, Daqing, Heilongjiang 163319, P.R. China School of Life Sciences, KUN Creative Bioresearch Group, Kyungpook National University, Daegu, Gyeongsangbuk 702‑701, Republic of Korea Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology, Ibam‑myeon, Jeongeup‑si, Jeonbuk 56216, Republic of Korea AU - Jin,Mei‑Hua AU - Shen,Gui‑Nan AU - Jin,Ying‑Hua AU - Sun,Hu‑Nan AU - Zhen,Xing AU - Zhang,Yong‑Qing AU - Lee,Dong‑Seok AU - Cui,Yu‑Dong AU - Yu,Li‑Yun AU - Kim,Ji‑Su AU - Kwon,Taeho AU - Han,Ying‑Hao DA - 2020/09/01 DO - 10.3892/mmr.2020.11279 EP - 1838 IS - 3 JO - Mol Med Rep KW - peroxiredoxin I apoptosis streptozotocin β‑cell glycogen synthase kinase‑3β signaling PY - 2020 SN - 1791-2997 1791-3004 SP - 1831 ST - Peroxiredoxin I deficiency increases pancreatic β‑cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway T2 - Molecular Medicine Reports TI - Peroxiredoxin I deficiency increases pancreatic β‑cell apoptosis after streptozotocin stimulation via the AKT/GSK3β signaling pathway UR - https://doi.org/10.3892/mmr.2020.11279 VL - 22 ER -