TY - JOUR AB - Alterations in molecular signaling impair cellular functions and induce degenerative diseases. Among the factors affecting intracellular signaling pathways, oxidative stress serves an important role. Astaxanthin (3,3'‑dihydroxy‑β, β‑carotene-4,4'‑dione), a pigment found in aquatic organisms, belongs to the xanthophylls family. Astaxanthin exerts a strong antioxidant activity and is widely used in food, cosmetic and pharmaceutical industries. Oxidative stress damages bone homeostasis by producing reactive oxygen species and increasing the production of pro‑resorption cytokines, such as interleukin (IL)‑1, tumor necrosis factor‑α and IL‑6. Therefore, antioxidant molecules can counteract the negative effects of oxidative stress on bone. Accordingly, previous studies have demonstrated that supplementation of astaxanthin in bone contributes to the restoration of bone homeostasis. The present review summarizes the negative effects of oxidative stress in bone and explores the role of astaxanthin in counteracting skeletal injuries consequent to oxidative stress. AD - Department of Medicine, University of Verona, 37100 Verona, Italy Department of Biotechnology, University of Verona, 37100 Verona, Italy Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100 Verona, Italy AU - Valenti,Maria Teresa AU - Perduca,Massimiliano AU - Romanelli,Maria Grazia AU - Mottes,Monica AU - Dalle Carbonare,Luca DA - 2020/09/01 DO - 10.3892/mmr.2020.11284 EP - 1701 IS - 3 JO - Mol Med Rep KW - oxidative stress reactive oxygen species bone remodeling astaxanthin antioxidant PY - 2020 SN - 1791-2997 1791-3004 SP - 1695 ST - A potential role for astaxanthin in the treatment of bone diseases (Review) T2 - Molecular Medicine Reports TI - A potential role for astaxanthin in the treatment of bone diseases (Review) UR - https://doi.org/10.3892/mmr.2020.11284 VL - 22 ER -