TY - JOUR AB - Taurine (2‑aminoethanesulfonic acid) contributes to homeostasis, mainly through its antioxidant and osmoregulatory properties. Taurine's influx and efflux are mainly mediated through the ubiquitous expression of the sodium/chloride‑dependent taurine transporter, located on the plasma membrane. The significance of the taurine transporter has been shown in various organ malfunctions in taurine‑transporter‑null mice. The taurine transporter differentially responds to various cellular stimuli including ionic environment, electrochemical charge, and pH changes. The renal system has been used as a model to evaluate the factors that significantly determine the regulation of taurine transporter regulation. AD - National Hellenic Research Foundation, 11635 Athens, Greece Nasco AD Biotechnology Laboratory, 18536 Pireus, Greece Department of Electron Microscopy and Molecular Pathology, The Cyprus Institute of Neurology and Genetics, 2371 Nicosia, Cyprus Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece AU - Baliou,Stella AU - Kyriakopoulos,Anthony ,M. AU - Goulielmaki,Maria AU - Panayiotidis,Michalis ,I. AU - Spandidos,Demetrios ,A. AU - Zoumpourlis,Vassilios DA - 2020/09/01 DO - 10.3892/mmr.2020.11321 EP - 2173 IS - 3 JO - Mol Med Rep KW - taurine transporter regulation taurine deficient conditions PY - 2020 SN - 1791-2997 1791-3004 SP - 2163 ST - Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review) T2 - Molecular Medicine Reports TI - Significance of taurine transporter (TauT) in homeostasis and its layers of regulation (Review) UR - https://doi.org/10.3892/mmr.2020.11321 VL - 22 ER -