TY - JOUR AB - Abnormal menstruation may result in several pathological alterations and gynaecological diseases, including endometriosis, menstrual pain and miscarriage. However, the pathogenesis of menstruation remains unclear due to the limited number of animal models available to study the menstrual cycle. In recent years, an effective, reproducible, and highly adaptive mouse model to study menstruation has been developed. In this model, progesterone and oestrogen were administered in cycles following the removal of ovaries. Subsequently, endometrial decidualisation was induced using sesame oil, followed by withdrawal of progesterone administration. Vaginal bleeding in mice is similar to that in humans. Therefore, the use of mice as a model organism to study the mechanism of menstruation and gynaecological diseases may prove to be an important breakthrough. The present review is focussed ond the development and applications of a mouse model of menstruation. Furthermore, various studies have been described to improve this model and the research findings that may aid in the treatment of menstrual disorders in women are presented. AD - Department of Pathophysiology, School of Basic Medicine Sciences, Nanchang University Medical College, Nanchang, Jiangxi 330006, P.R. China AU - Liu,Ting AU - Shi,Fuli AU - Ying,Ying AU - Chen,Qiongfeng AU - Tang,Zhimin AU - Lin,Hui DA - 2020/12/01 DO - 10.3892/mmr.2020.11567 EP - 4474 IS - 6 JO - Mol Med Rep KW - endometrium gynaecology menstruation model NF‑κB shedding repair PY - 2020 SN - 1791-2997 1791-3004 SP - 4463 ST - Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review) T2 - Molecular Medicine Reports TI - Mouse model of menstruation: An indispensable tool to investigate the mechanisms of menstruation and gynaecological diseases (Review) UR - https://doi.org/10.3892/mmr.2020.11567 VL - 22 ER -