TY - JOUR AB - Age‑related renal diseases, which account for various progressive renal disorders associated with cellular and organismal senescence, are becoming a substantial public health burden. However, their aetiologies are complicated and their pathogeneses remain poorly understood. Telomeres and telomerase are known to be essential for maintaining the integrity and stability of eukaryotic genomes and serve crucial roles in numerous related signalling pathways that activate renal functions, such as repair and regeneration. Previous studies have reported that telomere dysfunction served a role in various types of age‑related kidney disease through various different molecular pathways. The present review aimed to summarise the current knowledge of the association between telomeres and ageing‑related kidney diseases and explored the contribution of dysfunctional telomeres to these diseases. The findings may help to provide novel strategies for treating patients with renal disease. AD - Laboratory of Molecular Genetics of Aging and Tumor, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China The Key Lab of Sports and Rehabilitation, Faculty of Physical Education, Yuxi Normal University, Yuxi, Yunnan 653100, P.R. China Department of Human Anatomy, School of Basic Medicine and Institute of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong 250014, P.R. China Department of General Surgery, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China AU - Li,Haili AU - Wang,Boyuan AU - Li,Daoqun AU - Li,Jinyuan AU - Luo,Ying AU - Dan,Juhua DA - 2021/02/01 DO - 10.3892/mmr.2020.11735 IS - 2 JO - Mol Med Rep KW - telomeres telomerase age‑related renal diseases PY - 2021 SN - 1791-2997 1791-3004 SP - 96 ST - Roles of telomeres and telomerase in age‑related renal diseases (Review) T2 - Molecular Medicine Reports TI - Roles of telomeres and telomerase in age‑related renal diseases (Review) UR - https://doi.org/10.3892/mmr.2020.11735 VL - 23 ER -