TY - JOUR AB - Colorectal cancer (CRC) is the third most common malignant tumor in humans. Chemotherapy is used for the treatment of CRC. However, the effect of chemotherapy remains unsatisfactory due to drug resistance. Growing evidence has shown that the presence of highly metastatic tumor stem cells, regulation of non‑coding RNAs and the tumor microenvironment contributes to drug resistance mechanisms in CRC. Wnt/β‑catenin signaling mediates the chemoresistance of CRC in these three aspects. Therefore, the present study analyzed the abundant evidence of the contribution of Wnt/β‑catenin signaling to the development of drug resistance in CRC and discussed its possible role in improving the chemosensitivity of CRC, which may provide guidelines for its clinical treatment. AD - Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China AU - Zhu,Gui-Xian AU - Gao,Dian AU - Shao,Zhao-Zhao AU - Chen,Li AU - Ding,Wen-Jie AU - Yu,Qiong-Fang DA - 2021/02/01 DO - 10.3892/mmr.2020.11744 IS - 2 JO - Mol Med Rep KW - colorectal cancer Wnt/β‑catenin signaling drug resistance tumor stem cells non-coding RNAs tumor microenvironment PY - 2021 SN - 1791-2997 1791-3004 SP - 105 ST - Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review) T2 - Molecular Medicine Reports TI - Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review) UR - https://doi.org/10.3892/mmr.2020.11744 VL - 23 ER -