TY - JOUR AB - The aim of the present study was to investigate the neuroprotective effects of naringin on the memory impairment of hydrocortisone mice, and to elucidate the potential underlying molecular mechanisms. In the present study, a hydrocortisone model was constructed. Novel object recognition, Morris water maze and step‑down tests were performed in order to assess the learning and memory abilities of mice. Hematoxylin and eosin staining was used to observe pathological changes in the hippocampus and hypothalamus. Transmission electron microscopy was used to observe the ultrastructural changes in the hippocampus. Immunohistochemistry was used to detect the expression of ERα and ERβ. Western blotting was performed to detect the expression of each protein in the relevant system. It was found that naringin can significantly improve cognitive, learning and memory dysfunction in mice with hydrocortisone memory impairment. In addition, naringin can exert neuroprotective effects through a variety of mechanisms, including amyloid β metabolism, Tau protein hyperphosphorylation, acetylcholinergic system, glutamate receptor system, oxidative stress and cell apoptosis. Naringin can also affect the expression of phosphorylated‑P38/P38, indicating that the neuroprotective effect of naringin may also involve the MAPK/P38 pathway. The results of the present study concluded that naringin can effectively improve the cognitive abilities of mice with memory impairment and exert neuroprotective effects. Thus, naringin may be a promising target drug candidate for the treatment of Alzheimer's disease. AD - Nanchong Central Hospital, Second Clinical Medical College, Nanchong, Sichuan 637000, P.R. China Foreign Language Department, North Sichuan Medical College (University), Nanchong, Sichuan 637000, P.R. China Affiliated First Hospital, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China College of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China Jiamusi College, College of Pharmacy, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154007, P.R. China AU - Meng,Xiangdong AU - Fu,Mingming AU - Wang,Shoufeng AU - Chen,Weida AU - Wang,Jianjie AU - Zhang,Ning DA - 2021/05/01 DO - 10.3892/mmr.2021.11971 IS - 5 JO - Mol Med Rep KW - Alzheimer's disease memory impairment naringin amyloid‑β apoptosis PY - 2021 SN - 1791-2997 1791-3004 SP - 332 ST - Naringin ameliorates memory deficits and exerts neuroprotective effects in a mouse model of Alzheimer's disease by regulating multiple metabolic pathways T2 - Molecular Medicine Reports TI - Naringin ameliorates memory deficits and exerts neuroprotective effects in a mouse model of Alzheimer's disease by regulating multiple metabolic pathways UR - https://doi.org/10.3892/mmr.2021.11971 VL - 23 ER -