TY - JOUR AB - Type 2 innate lymphoid cells (ILC2s) are important innate immune cells that are involved in type 2 inflammation, in both mice and humans. ILC2s are stimulated by factors, including interleukin (IL)‑33 and IL‑25, and activated ILC2s secrete several cytokines that mediate type 2 immunity by inducing profound changes in physiology, including activation of alternative (M2) macrophages. M2 macrophages possess immune modulatory, phagocytic, tissue repair and remodeling properties, and can regulate ILC2s under infection. The present review summarizes the role of ILC2s as innate cells and M2 macrophages as anti‑inflammatory cells, and discusses current literature on their important biological significance. The present review also highlights how the crosstalk between ILC2s and M2 macrophages contributes to lung development, induces pulmonary parasitic expulsion, exacerbates pulmonary viral and fungal infections and allergic airway diseases, and promotes the development of lung diseases, such as pulmonary fibrosis, chronic obstructive pulmonary disease and carcinoma of the lungs. AD - Department of Pediatrics, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China AU - Mi,Lan-Lan AU - Zhu,Yue AU - Lu,Hong-Yan DA - 2021/06/01 DO - 10.3892/mmr.2021.12042 IS - 6 JO - Mol Med Rep KW - type 2 innate lymphoid cells alternative macrophages crosstalk lung development lung diseases PY - 2021 SN - 1791-2997 1791-3004 SP - 403 ST - A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review) T2 - Molecular Medicine Reports TI - A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review) UR - https://doi.org/10.3892/mmr.2021.12042 VL - 23 ER -