TY - JOUR AB - MicroRNAs (miRs) are endogenous, small, non‑coding RNA molecules with ~22 nucleotides, and are involved in regulating the expression of multiple genes and controlling cellular functions. miRs serve key roles in angiogenesis by regulating the proliferation, differentiation, apoptosis and migration of endothelial cells. Regulation of angiogenesis is essential for several physiological and pathological processes, particularly for tumor development and progression. Therefore, it is important to investigate the roles served by miRs in angiogenesis as this may aid in discovering novel strategies for treating tumors via modulating angiogenesis. In this review, miRNA biogenesis, regulation and functions are described with new information and corresponding references. In particular, the latest advances in the role of various miRs and their target genes involved in tumor angiogenesis were updated. Next, different signaling pathways by which miRNAs could be regulated in different types of tumor progression were addressed. Furthermore, the potential clinical value of miRs as biomarkers for diagnosing and monitoring the response to therapy, as well as their ability to regulate tumor angiogenesis and the mechanism underlying this regulation, were investigated. AD - Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China AU - Zheng,Qi AU - Hou,Wei DA - 2021/08/01 DO - 10.3892/mmr.2021.12222 IS - 2 JO - Mol Med Rep KW - angiogenesis microRNA cancer regulation biomarker PY - 2021 SN - 1791-2997 1791-3004 SP - 583 ST - Regulation of angiogenesis by microRNAs in cancer T2 - Molecular Medicine Reports TI - Regulation of angiogenesis by microRNAs in cancer UR - https://doi.org/10.3892/mmr.2021.12222 VL - 24 ER -