TY - JOUR AB - Liver fibrosis is a common pathological process of chronic liver diseases, including viral hepatitis and alcoholic liver disease, and ultimately progresses to irreversible cirrhosis and cancer. Hepatic stellate cells (HSCs) are activated to produce amounts of collagens in response to liver injury, thus triggering the initiation and progression of fibrogenesis. Natural killer (NK) cells serve as the essential component of hepatic innate immunity and are considered to alleviate fibrosis by killing activated HSCs. Current antifibrotic interventions have improved fibrosis, but fail to halt its progression in the advanced stage. Clarifying the interaction between NK cells and HSCs will provide clues to the pathogenesis and potential therapies for advanced liver fibrosis. AD - Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China The Graduate School, Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China Department of Gynaecology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China Department of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, Heilongjiang 150001, P.R. China AU - Zhang,Yang AU - Wu,Yuan AU - Shen,Wenjuan AU - Wang,Bingyu AU - Yuan,Xingxing DA - 2022/06/01 DO - 10.3892/mmr.2022.12724 IS - 6 JO - Mol Med Rep KW - natural killer cells fibrosis hepatic stellate cells crosstalk TGF‑β PY - 2022 SN - 1791-2997 1791-3004 SP - 208 ST - Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review) T2 - Molecular Medicine Reports TI - Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review) UR - https://doi.org/10.3892/mmr.2022.12724 VL - 25 ER -