TY - JOUR AB - In recent decades, studies have reported that inflammation serves key roles in epilepsy and that high mobility group box protein‑1 (HMGB1) may be involved in status epilepticus. However, it has not been reported whether HMGB1 participates in the pathogenesis of status epilepticus through the regulation of the p38 mitogen‑activated protein kinase (p38MAPK) signalling pathway. In the present study, Sprague‑Dawley rats were randomly divided into four groups as follows: Control, status epilepticus (SE), dimethyl sulfoxide treatment (DMSO + SE), and glycyrrhizin treatment (GL + SE) groups. Behavioural changes were then evaluated using the Racine score. In the hippocampus, the protein expression levels of HMGB1 were assessed using western blotting, the neuronal damage was evaluated using haematoxylin and eosin staining and transmission electron microscopy, and the activation of microglia was assessed using immunochemistry and immunofluorescence. The results demonstrated that, in the hippocampal region, HMGB1 existed in neurons and astrocytes and the protein expression levels of HMGB1, p38MAPK and phosphorylated‑p38MAPK were significantly inhibited after treatment with GL. Furthermore, GL could alleviate neuronal injury in the CA1 region of the hippocampus and prevented HMGB1 translocation from the nucleus into the cytoplasm in these areas. These findings expand the understanding of how HMGB1 may participate in SE and lay a foundation for evaluation of HMGB1 as a drug target. AD - Department of Neurology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China AU - Luo,Zhong AU - Xu,Meng AU - Zhang,Linhai AU - Zhang,Haiqing AU - Xu,Zucai AU - Xu,Zhongxiang DA - 2023/02/01 DO - 10.3892/mmr.2023.12932 IS - 2 JO - Mol Med Rep KW - status epilepticus Glycyrrhizin high mobility group box protein‑1 p38 mitogen‑activated protein kinase PY - 2023 SN - 1791-2997 1791-3004 SP - 45 ST - Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus T2 - Molecular Medicine Reports TI - Glycyrrhizin regulates the HMGB1/P38MAPK signalling pathway in status epilepticus UR - https://doi.org/10.3892/mmr.2023.12932 VL - 27 ER -