TY - JOUR AB - Wound healing is a very complex process of interactions between different cells, growth factors, blood elements and extracellular matrix. Keloids represent one of the possible complications in the fundamental process of cutaneous wound repair. Despite all efforts, keloids remain a therapeutic challenge since no treatment is as yet considered 100% effective. Growth factors, discovered in the late 1970s, have been shown to influence dermal regeneration. However, the exogenous application of growth factors to chronic wounds has not proven to be effective in healing them. Additionally, genetic analysis has not revealed any single gene that might cause keloids; as such, classic gene therapy is not a feasible option for the treatment of keloids. A new approach is so-called somatic gene therapy. This review provides an overview of the fundamentals of wound healing and of keloids, and presents new possibilities that may improve cutaneous wound repair. AD - Klinik für Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, HSK, Dr Horst Schmidt Kliniken GmbH, 65199 Wiesbaden, Germany. mkgieringer@gmail.com null AU - Gieringer,Matthias AU - Elliott,Katharine AU - Gosepath,Jan AU - Naim,Ramin DA - 2010/01/01 DO - 10.3892/mmr_00000212 EP - 19 IS - 1 JO - Mol Med Rep PY - 2010 SN - 1791-2997 1791-3004 SP - 13 ST - Keloids: Fundamental principles and prospects (Review) T2 - Molecular Medicine Reports TI - Keloids: Fundamental principles and prospects (Review) UR - https://doi.org/10.3892/mmr_00000212 VL - 3 ER -