TY - JOUR AB - Salinomycin is a monocarboxylic polyether ionophore isolated from Streptomyces albus that has been used for more than 30 years as an agricultural antibiotic to prevent coccidiosis in poultry and to improve nutrient absorption and feed efficiency in ruminants and swine. As a inonophore with strict selectivety for alkali ions and a strong preference for potassium, salinomycin interferes with transmembrane potassium potential and promotes the efflux of K+ ions from mitochondria and cytoplasm. Salinomycin has recently been shown to kill human cancer stem cells and to inhibit breast cancer growth and metastasis in mice. Salinomycin is also able to induce massive apoptosis in human cancer cells of different origins that display multiple mechanisms of drug and apoptosis resistance. Salinomycin activates an unconventional pathway of apoptosis in human cancer cells that may contribute to the breakdown of apoptosis resistance. The ability of salinomycin to effectively kill both cancer stem cells and apoptosis-resistant cancer cells may define the compound as a novel and effective anticancer agent. AD - Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, D-69120 Heidelberg, Germany. cord.naujokat@med.uni-heidelberg.de null AU - Naujokat,Cord AU - Fuchs,Dominik AU - Opelz,Gerhard DA - 2010/07/01 DO - 10.3892/mmr_00000296 EP - 559 IS - 4 JO - Mol Med Rep PY - 2010 SN - 1791-2997 1791-3004 SP - 555 ST - Salinomycin in cancer: A new mission for an old agent T2 - Molecular Medicine Reports TI - Salinomycin in cancer: A new mission for an old agent UR - https://doi.org/10.3892/mmr_00000296 VL - 3 ER -