TY - JOUR AB - Research on polycyclic aromatic hydrocarbons and their derivatives has received significant attention from the scientific community. The present study involved the synthesis of several novel 6,12-disubstituted chrysene derivatives. Nitration of chrysene with nitric acid produced 6,12-dinitrochrysene which when reduced yielded 6,12-diaminochrysene. A coupling reaction of 6,12-diaminochrysene with an acid in the presence of isobutylchloroformate produced amide. The reduction of amide produced an amine. The amino was converted to a hydrochloride salt. The new compounds were characterized through different types of analytical data. One of these compounds demonstrated marked activity in vivo against a colon cancer cell line. Inhibition of the growth of this tumor was best noted at day 20 when each treatment regimen inhibited the average tumor volume by 50%. In a number of in vivo tests in various regimens, the hydrochloride salt demonstrated consistent inhibition of the growth of the cancer HT-29 cell line. Despite the research progress in polycyclic aromatic compounds, the use of these types of molecules as anticancer agents has not been reported systematically. AD - Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, Texas 78539, USA Department of Molecular Pathology, M. D. Anderson Cancer Center, Unit 951, The University of Texas, Houston, Texas 77030, USA AU - Banik,Bimal,B. AU - Basu,Manas,K. AU - Becker,Fredrick,F. DA - 2010/11/01 DO - 10.3892/ol.2010.167 EP - 1036 IS - 6 JO - Oncol Lett KW - chrysene derivative colon cancer cell line in vivo test PY - 2010 SN - 1792-1074 1792-1082 SP - 1033 ST - Novel disubstituted chrysene as a potent agent against colon cancer T2 - Oncology Letters TI - Novel disubstituted chrysene as a potent agent against colon cancer UR - https://doi.org/10.3892/ol.2010.167 VL - 1 ER -