TY - JOUR AB - Carcinoma of unknown primary origin (CUP) is defined as the histological diagnosis of metastasis without the detection of a primary tumor. The incidence of CUP in all patients with a malignant disease has been reported to be between 3 and 15%. Esophageal cancer is the third most common type of cancer of the digestive tract and the seventh most common cause of cancer-related mortality worldwide. The overall incidence of the disease is highest in males >50 years old. Brain metastases have been reported in only 1.7-3.6% of all patients with different types of esophageal cancer. Brain metastasis as the presenting form of esophageal carcinoma is highly uncommon. The present study reports the case of a patient with an unknown primary tumor who presented with a cerebral metastasis, without extra‑neurological symptoms. The CUP was subsequently diagnosed as an esophageal carcinoma. AD - Section of Neurosurgery, Department of Clinical Neurosciences, Neurological Centre of Latium (NCL), Rome I-00178, Italy AU - Spallone,Aldo AU - Izzo,Chiara DA - 2013/09/01 DO - 10.3892/ol.2013.1436 EP - 724 IS - 3 JO - Oncol Lett KW - brain metastasis esophageal cancer unknown primary carcinoma PY - 2013 SN - 1792-1074 1792-1082 SP - 722 ST - Esophageal cancer presenting as a brain metastasis: A case report T2 - Oncology Letters TI - Esophageal cancer presenting as a brain metastasis: A case report UR - https://doi.org/10.3892/ol.2013.1436 VL - 6 ER -