TY - JOUR AB - Peutz‑Jeghers syndrome (PJS) is an autosomal dominant disease that is characterized by gastrointestinal hamartomatous polyposis and mucocutaneous melanin spots. The tumor suppressor gene, STK11/LKB1, which is located on chromosome 19p13.3, has been reported to be responsible for this condition. PJS is complicated by benign and malignant tumors of various organs and complications from rare diseases, including sex cord tumor with annular tubules (SCTAT) and minimal deviation adenocarcinoma (MDA), which have also recently attracted attention in the field of gynecology. Among the total MDA cases, 10% are complications of PJS, and mutations in the STK11 gene are closely associated with the development and prognosis of MDA. Furthermore, a new type of uterine cervical tumor, lobular endocervical glandular hyperplasia (LEGH), has been identified and has been predicted to be a precancerous lesion of MDA. The first case of LEGH induced by a germline STK11 mutation has also been described. A high risk of endometrial cancer in PJS has also been reported. These developments suggest that PJS is an important syndrome of hereditary gynecological tumors that requires further study. AD - Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo 160-8582, Japan AU - Banno,Kouji AU - Kisu,Iori AU - Yanokura,Megumi AU - Masuda,Kenta AU - Ueki,Arisa AU - Kobayashi,Yusuke AU - Hirasawa,Akira AU - Aoki,Daisuke DA - 2013/11/01 DO - 10.3892/ol.2013.1527 EP - 1188 IS - 5 JO - Oncol Lett KW - Peutz‑Jeghers syndrome sex cord tumor minimal deviation adenocarcinoma lobular endocervical glandular hyperplasia STK11/LKB1 endometrial cancer PY - 2013 SN - 1792-1074 1792-1082 SP - 1184 ST - Hereditary gynecological tumors associated with Peutz‑Jeghers syndrome (Review) T2 - Oncology Letters TI - Hereditary gynecological tumors associated with Peutz‑Jeghers syndrome (Review) UR - https://doi.org/10.3892/ol.2013.1527 VL - 6 ER -