TY - JOUR AB - Resistance to chemotherapy is a major clinical issue for patients with colorectal cancer. Obesity has been associated with a poorer outcome and is a possible mechanism of resistance. The aim of the present study was to investigate the effect of obesity‑related factors on the cell response to standard chemotherapy in stromal and colorectal cancer cells. Viability was measured following the treatment of colorectal cancer cell lines (WiDr and SW620) and stromal cells (human microvascular endothelial cells) in vitro with 5‑fluorouracil, irinotecan and oxaliplatin under obesity‑related conditions [elevated levels of insulin, insulin‑like growth factor‑1 (IGF‑1) and glucose] and compared with non‑elevated conditions. Obesity‑related conditions alone increased cell viability and in selected cases, accumulation of the transcription factor, hypoxia‑inducible factor‑1. However, these conditions did not consistently increase resistance to the chemotherapy agents tested. The combination of IGF‑1 and extremely low‑dose chemotherapy significantly induced cell viability in WiDr colorectal cancer cells. These in vitro results may have clinical importance in an environment of increasing rates of obesity and colorectal cancer, and the frequent under‑dosing of obese cancer patients. AD - Mackenzie Cancer Research Group, Department of Pathology, University of Otago Christchurch, Christchurch 8140, New Zealand Lipid and Diabetes Research Group, Christchurch Hospital, Christchurch 8140, New Zealand AU - Volkova,Ekaterina AU - Robinson,Bridget,A. AU - Willis,Jinny AU - Currie,Margaret,J. AU - Dachs,Gabi,U. DA - 2014/02/01 DO - 10.3892/ol.2013.1710 EP - 320 IS - 2 JO - Oncol Lett KW - proliferation stroma low dose fluorouracil irinotecan oxaliplatin PY - 2014 SN - 1792-1074 1792-1082 SP - 311 ST - Marginal effects of glucose, insulin and insulin‑like growth factor on chemotherapy response in endothelial and colorectal cancer cells T2 - Oncology Letters TI - Marginal effects of glucose, insulin and insulin‑like growth factor on chemotherapy response in endothelial and colorectal cancer cells UR - https://doi.org/10.3892/ol.2013.1710 VL - 7 ER -