TY - JOUR AB - Carbohydrate metabolism disorders increase the risk of carcinogenesis. Diabetes mellitus alters numerous physiological processes that may encourage cancer growth. However, treating impaired glucose homeostasis may actually promote neoplasia; maintaining proper glucose plasma concentrations reduces metabolic stresses, however, certain medications may themselves result in oncogenic effects. A number of previous studies have demonstrated that metformin reduces the cancer risk. However, the use of sulfonylurea derivatives correlates with an increased risk of developing a malignancy. Another form of treatment, insulin therapy, involves using various forms of insulin that differ in pharmacodynamics, pharmacokinetics and efficacy. Previous studies have indicated that certain insulin variants also affect the cancer risk. The results from analyses that address the safety of long‑lasting insulin types raise the most concern regarding the increased risk of malignancy. Rapid development of novel diabetic medications and their widespread use carries the risk of potentially increased rates of cancer, unnoticeable in limited, randomized, controlled trials. In the present review, the results of clinical and epidemiological studies are evaluated to assess the safety of anti‑hyperglycemic medications and their effect on cancer risk and outcomes. AD - Department of Oncology, Military Institute of Medicine, Warsaw, Poland Department of Urology, Emory University School of Medicine, Atlanta, GA, USA Department of Otorhinolaryngology, Medical University of Warsaw, Warsaw, Poland AU - Matyszewski,Artur AU - Czarnecka,Anna AU - Kawecki,Maciej AU - Korzeń,Piotr AU - Safir,Ilan,J. AU - Kukwa,Wojciech AU - Szczylik,Cezary DA - 2015/08/01 DO - 10.3892/ol.2015.3324 EP - 594 IS - 2 JO - Oncol Lett KW - carcinogenesis diabetes insulin resistance glargine metformin PY - 2015 SN - 1792-1074 1792-1082 SP - 589 ST - Impaired glucose metabolism treatment and carcinogenesis (Review) T2 - Oncology Letters TI - Impaired glucose metabolism treatment and carcinogenesis (Review) UR - https://doi.org/10.3892/ol.2015.3324 VL - 10 ER -