TY - JOUR AB - Cancer remains one of the leading causes of human mortality worldwide. Radiation and chemotherapy are commonly used for cancer treatment; however, the combination of these therapies and surgery do not completely eradicate cancer cells. Near‑infrared radiation (NIR) is a low‑energy form of radiation that exerts multiple effects on mammalian cells. Previous studies have reported that NIR induces DNA double‑strand breaks and apoptosis of cancer cells. In the present study, a 915‑nm laser was used to examine the effects of NIR on pancreatic cancer cells. Irradiation of pancreatic cancer cells using a 915‑nm laser significantly induced caspase‑3 activation and apoptosis. In addition, the combination of gemcitabine treatment and a 915‑nm laser synergistically increased the number of apoptotic cells. The results of the present study indicate the use of infrared irradiation and chemotherapy may be a possible therapy for the treatment of cancer. AD - Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan Division of Cancer Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan AU - Obayashi,Tomohiko AU - Funasaka,Kohei AU - Ohno,Eizaburo AU - Miyahara,Ryoji AU - Hirooka,Yoshiki AU - Hamaguchi,Michinari AU - Goto,Hidemi AU - Senga,Takeshi DA - 2015/09/01 DO - 10.3892/ol.2015.3399 EP - 1840 IS - 3 JO - Oncol Lett KW - near-infrared radiation apoptosis gemcitabine caspase-3 pancreatic cancer PY - 2015 SN - 1792-1074 1792-1082 SP - 1836 ST - Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells T2 - Oncology Letters TI - Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells UR - https://doi.org/10.3892/ol.2015.3399 VL - 10 ER -