TY - JOUR AB - Unlike other cyclins that positively regulate the cell cycle, cyclin G2 (CCNG2) regulates cell proliferation as a tumor suppressor gene. A decreased CCNG2 expression serves as a marker for poor prognosis in several types of cancer. The aim of the present study was to clarify the correlation of CCNG2 expression with overall survival and histopathological factors in pancreatic cancer patients. This retrospective analysis included data from 36 consecutive patients who underwent complete surgical resection for pancreatic cancer and did not undergo any preoperative therapies. The association between prognoses and the expression of CCNG2 was assessed using immunohistochemical staining. Multivariate analysis identified that the expression of CCNG2 is an independent prognostic factor. In addition, the Kaplan‑Meier curve for overall survival revealed that decreased expression of CCNG2 was a consistent indicator of poor prognosis in pancreatic cancer patients (P=0.0198). A decreased CCNG2 expression significantly correlated with venous invasion in tumor specimens and the tumor invasion depth. In conclusion, CCNG2 expression inversely reflected cancer progression and may be a novel, independent prognostic marker in pancreatic cancer. AD - Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan Department of Frontier Science for Cancer and Chemotherapy, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan Department of Cancer Profiling Discovery, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan Division of Cancer Cell Biology, Cancer Research Institute of Kanazawa University, Kanazawa 920‑1192, Japan Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, Osaka 565‑0871, Japan AU - Hasegawa,Shinichiro AU - Nagano,Hiroaki AU - Konno,Masamitsu AU - Eguchi,Hidetoshi AU - Tomokuni,Akira AU - Tomimaru,Yoshito AU - Wada,Hiroshi AU - Hama,Naoki AU - Kawamoto,Koichi AU - Kobayashi,Shogo AU - Marubashi,Shigeru AU - Nishida,Naohiro AU - Koseki,Jun AU - Gotoh,Noriko AU - Ohno,Shouichi AU - Yabuta,Norikazu AU - Nojima,Hiroshi AU - Mori,Masaki AU - Doki,Yuichiro AU - Ishii,Hideshi DA - 2015/11/01 DO - 10.3892/ol.2015.3667 EP - 2990 IS - 5 JO - Oncol Lett KW - immunohistochemical staining cyclin G2 pancreatic cancer overall survival PY - 2015 SN - 1792-1074 1792-1082 SP - 2986 ST - Cyclin G2: A novel independent prognostic marker in pancreatic cancer T2 - Oncology Letters TI - Cyclin G2: A novel independent prognostic marker in pancreatic cancer UR - https://doi.org/10.3892/ol.2015.3667 VL - 10 ER -