TY - JOUR AB - MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through the direct targeting of oncogenes or tumor suppressors. It has been previously suggested that miR‑126 may be associated with endometrial cancer (EC). However, the exact role of miR‑126 in the migration and invasion of EC cells has not yet been studied. The present study demonstrated that the expression of miR‑126 was significantly decreased in EC tissues when compared with matched normal adjacent tissues. The current study reverse transcription-quantitative polymerase chain reaction was performed in order to examine the expression level of miR-126. Wound healing and transwell assays were used to examine cell migration and invasion. A luciferase reporter assay was used to determine the targeting relationship and western blotting assay was performed to detect the protein expression. Furthermore, the overexpression of miR‑126 significantly inhibited EC SKOV3 cell migration and invasion. Molecular mechanism investigation established that insulin receptor substrate 1 (IRS1) functioned as a direct miR‑126 target, and its expression was negatively regulated by miR‑126 at a post‑transcriptional level in the SKOV3 cells. Additionally, the overexpression of IRS1 reversed the inhibitory effect of miR‑126 overexpression on SKOV3 cell migration and invasion. In conclusion, the current study demonstrated that miR‑126 inhibited EC cell migration and invasion, at least partially through the direct targeting of IRS1, suggesting that miR‑126 may aid the treatment of EC metastasis. AD - Department of Obstetrics and Gynecology, The First People's Hospital of Taizhou City, Taizhou, Zhejiang 318020, P.R. China AU - Zhao,Xiumin AU - Zhu,Danyang AU - Lu,Cailing AU - Yan,Dewen AU - Li,Lifeng AU - Chen,Zhoufang DA - 2016/02/01 DO - 10.3892/ol.2015.4001 EP - 1212 IS - 2 JO - Oncol Lett KW - endometrial cancer microRNA-126 insulin receptor substrate 1 migration invasion PY - 2016 SN - 1792-1074 1792-1082 SP - 1207 ST - MicroRNA-126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1 Retraction in /10.3892/ol.2021.12906 T2 - Oncology Letters TI - MicroRNA-126 inhibits the migration and invasion of endometrial cancer cells by targeting insulin receptor substrate 1 Retraction in /10.3892/ol.2021.12906 UR - https://doi.org/10.3892/ol.2015.4001 VL - 11 ER -