TY - JOUR AB - The regulation of entry into and progression through mitosis is important for cell proliferation. Polo-like kinase 1 (PLK1) is involved in multiple stages of mitosis. Forkhead box protein M1 (FOXM1) has multiple functions in tumorigenesis and, in elevated levels, is frequently associated with cancer progression. The present study reports that FOXM1, a substrate of PLK1, controls the transcription mechanism that mediates the PLK1‑dependent regulation of the cell cycle. The present study investigated the expression of PLK1 and FOXM1 in the clear renal cell carcinoma 769‑P and ACHN cell lines, and indicated that the expression of PLK1 and FOXM1 are correlated in human renal cell cancer cell lines and that the suppression of PLK1 may decrease the expression of FOXM1. The knockdown of FOXM1 or PLK1 in renal cell cancer cell lines caused cell cycle progression to be blocked. As a result, the present study indicated the involvement of FOXM1 in PLK1-regulated cell cycle progression. AD - Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China AU - Zhang,Zhe AU - Zhang,Guojun AU - Kong,Chuize DA - 2016/04/01 DO - 10.3892/ol.2016.4228 EP - 2691 IS - 4 JO - Oncol Lett KW - renal cancer polo‑like kinase 1 cell proliferation forkhead box protein M1 cell cycle PY - 2016 SN - 1792-1074 1792-1082 SP - 2685 ST - FOXM1 participates in PLK1-regulated cell cycle progression in renal cell cancer cells T2 - Oncology Letters TI - FOXM1 participates in PLK1-regulated cell cycle progression in renal cell cancer cells UR - https://doi.org/10.3892/ol.2016.4228 VL - 11 ER -