TY - JOUR AB - The present study investigated the possible correlation between 18F-2-fluorodeoxyglucose (18F-FDG)-uptake parameters and clinicopathological parameters in hypopharyngeal squamous cell carcinoma (HPSCC). A total of 53 patients, newly diagnosed with HPSCC, received pretreatment 18F-FDG-positron emission tomography/computed tomography (PET/CT). Metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum and peak standardized uptake values (SUVmax and SUVpeak) were calculated as 18F‑FDG‑uptake parameters of the primary tumor. Tumor thickness, depth of invasion and pathological tumor volume were pathologically measured. Upon univariate survival analysis, SUVmax ≥28.5, SUVpeak ≥19, MTV ≥12 and TLG ≥42 were significantly associated with a shorter overall survival (OS) time, and MTV ≥12 and TLG ≥42 were significantly associated with a shorter distant metastasis‑free survival (DMFS) time. Upon multivariate analysis with adjustment for clinical T category and treatment group, patients with SUVmax ≥28.5 exhibited a significantly shorter OS time, while TLG ≥42 was significantly correlated with shorter OS and DMFS times. Upon simple regression analysis, TLG was found to be significantly associated with tumor thickness and depth of invasion, while MTV was found to be closely associated with pathological tumor volume. In conclusion, pretreatment 18F‑FDG‑PET/CT is likely to provide valuable prognostic parameters in HPSCC. AD - Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan Department of Radiology, Nagoya Positron Emission Tomography Imaging Center, Nagoya, Aichi 454‑0933, Japan Department of Pathology, Aichi Cancer Center Aichi Hospital, Okazaki, Aichi 444‑0011, Japan Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi 464‑8681, Japan Department of Radiology, East Nagoya Positron Emission Tomography Imaging Center, Nagoya, Aichi 464‑0044, Japan AU - Suzuki,Hidenori AU - Nishio,Masami AU - Nakanishi,Hayao AU - Hanai,Nobuhiro AU - Hirakawa,Hitoshi AU - Kodaira,Takeshi AU - Tamaki,Tsuneo AU - Hasegawa,Yasuhisa DA - 2016/08/01 DO - 10.3892/ol.2016.4765 EP - 1500 IS - 2 JO - Oncol Lett KW - hypopharyngeal squamous cell carcinoma 18F‑2‑fluorodeoxyglucose‑positron emission tomography/computed tomography 18F‑2‑fluorodeoxyglucose‑uptake parameter distant metastasis overall survival PY - 2016 SN - 1792-1074 1792-1082 SP - 1493 ST - Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer T2 - Oncology Letters TI - Impact of total lesion glycolysis measured by 18F-FDG-PET/CT on overall survival and distant metastasis in hypopharyngeal cancer UR - https://doi.org/10.3892/ol.2016.4765 VL - 12 ER -