TY - JOUR AB - Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs composed of >200 nucleotides. Recent studies have revealed that lncRNAs exert an important role in the development and progression of cancer. In this review, the involvement of the most extensively investigated lncRNAs in cancers of the digestive, respiratory, reproductive, urinary and central nervous systems are discussed. LncRNAs function via molecular and biochemical mechanisms that include cis‑ and trans‑regulation of gene expression, epigenetic modulation in the nucleus and post‑transcriptional control in the cytoplasm. Although the detailed biological functions and molecular mechanisms of the majority of lncRNAs remain to be elucidated, this review aims to provide a novel insight into the diagnosis and treatment of cancer using lncRNAs. AD - Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital, Shanghai 200233, P.R. China AU - Zhang,Rui AU - Xia,Li ,Qiong AU - Lu,Wen ,Wen AU - Zhang,Jing AU - Zhu,Jin‑Shui DA - 2016/08/01 DO - 10.3892/ol.2016.4770 EP - 1239 IS - 2 JO - Oncol Lett KW - long non‑coding RNA HOTAIR MALAT1 cancer PY - 2016 SN - 1792-1074 1792-1082 SP - 1233 ST - LncRNAs and cancer (Review) T2 - Oncology Letters TI - LncRNAs and cancer (Review) UR - https://doi.org/10.3892/ol.2016.4770 VL - 12 ER -