TY - JOUR AB - Glioma is the most common and aggressive type of primary brain tumor. MicroRNA (miR)‑130b functions as a tumor‑associated miR. The dysregulation of miR‑130b is involved in numerous biological characteristics and properties of certain types of cancer. The present study revealed the function and possible molecular mechanism of miR‑130b in glioma cells, reporting that the level of miR‑130b was markedly higher, increasing progressively as the histologic grade of the glioma increased, compared with the level in normal tissues. Additionally, the present study demonstrated that patients with high miR‑130b expression exhibited a poor 3‑year survival rate and miR‑130b was an independent factor for predicting the prognosis of patients with glioma. The downregulation of miR‑130b reduced invasion and migration in U373 and U87 cells. Furthermore, the downregulation of miR‑130b increased peroxisome proliferator‑activated receptor‑γ (PPARγ) expression and inhibited epithelial‑mesenchymal transition (EMT) in glioma cells. The present study identified PPARγ as a direct target of miR‑130b in glioma in vitro. Furthermore, PPARγ knockdown was revealed to reduce the effect on EMT caused by the downregulation of miR‑130b in U87 cells. The present study demonstrated that miR‑130b promotes glioma proliferation, migration and invasion by suppressing PPARγ and subsequently inducing EMT. AD - Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China AU - Li,Peidong AU - Wang,Xinjun AU - Shan,Qiao AU - Wu,Yuehui AU - Wang,Zhen DA - 2017/04/01 DO - 10.3892/ol.2017.5760 EP - 2622 IS - 4 JO - Oncol Lett KW - microRNA‑130b glioma peroxisome proliferator‑ activated receptor‑γ migration invasion PY - 2017 SN - 1792-1074 1792-1082 SP - 2615 ST - MicroRNA‑130b promotes cell migration and invasion by inhibiting peroxisome proliferator‑activated receptor‑γ in human glioma T2 - Oncology Letters TI - MicroRNA‑130b promotes cell migration and invasion by inhibiting peroxisome proliferator‑activated receptor‑γ in human glioma UR - https://doi.org/10.3892/ol.2017.5760 VL - 13 ER -