TY - JOUR AB - In the present study, the effects of the acetonitrile or water extracts from 400 selected traditional medicinal plants on the growth of PC-3 cells were investigated, and it was demonstrated that an acetonitrile extract of Salvia miltiorrhiza Radix exhibited the most marked cytotoxic effects on PC‑3 cells. It was observed that the acetonitrile extract of S. miltiorrhiza Radix induced marked cell cycle arrest and apoptosis in PC‑3 cells through the generation of intracellular reactive oxygen species. It was also demonstrated that oral administration of the acetonitrile extract of S. miltiorrhiza Radix decreased the incidence and growth of PC‑3 tumor xenografts in nude mice. The results of the present study suggest that the acetonitrile extract of S. miltiorrhiza Radix exhibits marked inhibitory effects on the growth of prostate cancer cells in vitro and in vivo. AD - College of Pharmacy, Dongguk University, Goyang, Gyeonggi 410‑820, Republic of Korea Department of Pharmaceutical Science and Engineering, Seowon University, Cheongju, Chungcheongbuk 361‑742, Republic of Korea AU - Lee,June AU - Choi,Bu ,Young AU - Keum,Young‑Sam DA - 2017/05/01 DO - 10.3892/ol.2017.5820 EP - 2928 IS - 5 JO - Oncol Lett KW - Salvia miltiorrhiza Radix prostate cancer cell cycle arrest apoptosis reactive oxygen species PY - 2017 SN - 1792-1074 1792-1082 SP - 2921 ST - Acetonitrile extract of Salvia miltiorrhiza Radix exhibits growth-inhibitory effects on prostate cancer cells through the induction of cell cycle arrest and apoptosis T2 - Oncology Letters TI - Acetonitrile extract of Salvia miltiorrhiza Radix exhibits growth-inhibitory effects on prostate cancer cells through the induction of cell cycle arrest and apoptosis UR - https://doi.org/10.3892/ol.2017.5820 VL - 13 ER -