TY - JOUR AB - P21-activated kinase 5 (PAK5), also termed PAK7, is one of the six members of the PAK family of serine/threonine kinases, which are downstream effectors in several cancer signaling pathways. PAK5 promotes neural outgrowth, contributes to microtubule stability and induces resistance to apoptosis. However, the clinical importance of PAK5 in gastric cancer has not been comprehensively investigated. In the present study, PAK5 expression was evaluated in gastric cancer tissue samples. Furthermore, the associations between high expression of PAK5, and clinicopathological features and prognosis were examined. PAK5 expression in primary gastric cancer specimens resected from 279 patients who underwent gastrectomy at the Tokyo Medical and Dental University Hospital was evaluated using immunohistochemistry. Of the 279 patients, 44 (15.8%) exhibited high PAK5 expression, which was significantly associated with the differentiated pathological type (differentiated vs. undifferentiated; P<0.001), depth of tumor invasion (T1 vs. T2‑T4; P<0.001), lymph node metastasis (N0 vs. N1‑N3; P<0.001), presence of distant metastasis or recurrence (present vs. absent; P=0.038), advanced tumor stage (I vs. II‑IV; P=0.001) and worse disease‑specific survival (P=0.013). In stage I‑III disease, 38/254 (15.0%) patients exhibited high PAK5 expression, and high expression of PAK5 was significantly associated with relapse‑free interval (P=0.044). PAK5 may serve an important role in tumor progression and influence the outcome of patients with gastric cancer. AD - Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo 113‑8519, Japan Department of Surgical Specialty, Tokyo Medical and Dental University, Tokyo 113‑8519, Japan AU - Aburatani,Tomoki AU - Inokuchi,Mikito AU - Takagi,Yoko AU - Ishikawa,Toshiaki AU - Okuno,Keisuke AU - Gokita,Kentaro AU - Tomii,Chiharu AU - Tanioka,Toshiro AU - Murase,Hideaki AU - Otsuki,Sho AU - Uetake,Hiroyuki AU - Kojima,Kazuyuki AU - Kawano,Tatsuyuki DA - 2017/07/01 DO - 10.3892/ol.2017.6115 EP - 410 IS - 1 JO - Oncol Lett KW - P21‑activated kinase 5 P21‑activated kinase 7 gastric cancer immunohistochemistry prognosis PY - 2017 SN - 1792-1074 1792-1082 SP - 404 ST - High expression of P21‑activated kinase 5 protein is associated with poor survival in gastric cancer T2 - Oncology Letters TI - High expression of P21‑activated kinase 5 protein is associated with poor survival in gastric cancer UR - https://doi.org/10.3892/ol.2017.6115 VL - 14 ER -