TY - JOUR AB - A long non-coding RNA named HOXA transcript at the distal tip (HOTTIP) has been reported to be significantly increased in several cancers, including hepatocellular cancer, pancreatic cancer and lung cancer. However, the clinical value of HOTTIP expression in gastric cancer remains unknown. The present study aimed to investigate HOTTIP expression levels in gastric cancer and to elucidate its clinical significance. Reverse transcription polymerase chain reaction was used to assess the expression level of HOTTIP in gastric cancer cell lines and tissues. In a cohort of 94 patients with gastric cancer, HOTTIP expression was significantly lower in cancer tissues compared with the normal adjacent tissues. In addition, receiver operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic value of HOTTIP in gastric cancer, and the area under the ROC curve was 0.767. In conclusion, the results of the present study indicated that HOTTIP may be a predictive biomarker for gastric cancer. AD - Department of Surgical Oncology and General Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Radiotherapy, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110016, P.R. China AU - Yang,Yuchong AU - Ma,Bin AU - Yan,Ying AU - Song,Yongxi AU - Gao,Peng AU - Sun,Jingxu AU - Wang,Jiajun AU - Wang,Zhenning DA - 2017/07/01 DO - 10.3892/ol.2017.6186 EP - 1072 IS - 1 JO - Oncol Lett KW - biomarker gastric cancer HOXA transcript at the distal tip long non‑coding RNA PY - 2017 SN - 1792-1074 1792-1082 SP - 1068 ST - Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer T2 - Oncology Letters TI - Long non-coding RNA HOXA transcript at the distal tip as a biomarker for gastric cancer UR - https://doi.org/10.3892/ol.2017.6186 VL - 14 ER -